PEPR TREASURE
The project at a glance
Seven complementary work packages, from data infrastructures to ethics and education.
- Electronic health records
- Registries & data warehouses
- Biology & immunology platforms (EFS, CRB, HLA labs)
- Biocollection
- Tissue collections
- Cloud storage & computing capacity
- Medical-fees data integration
- Augmented organ perfusion
- Long-duration normothermic perfusion & innovative evaluation
- Clinically augmented grafts (pancreatic islets, trachea)
- Immune monitoring: DNA, RNA, metabolites, proteins, cells, antibodies
- Allograft tissue-based diagnostics
- Avoiding futile biopsies
- Pathogenesis-based diagnostics
- Therapeutic target discovery
- Mechanistically informed therapeutics
- Risk stratification
- Automated rejection diagnostics
- Therapy adaptation (minimisation, intensification)
- Response to therapy
Augmented organs
- Increasing the pool of donor organs
- Enhancing the reconditioning of transplantable organs
- Advanced systems to assess viability and function
Augmented physicians
- Non-invasive biomarker prediction
- Digital & molecular microscope
- Automated diagnostics
- Patient prognostication (graft loss, death, infection, cancer, CV events)
AI patient copilot
- Remote monitoring
- LLM-based chatbot
- Patient-centred care
- Connected devices (IoT)
Augmented clinical trials
- Virtualised clinical trials
- Digital surrogate endpoints
- AI-based drug discovery & repurposing
- Digital twins
- Integration of ethical & regulatory dimensions
- Financial barriers & value-based healthcare
- Training future transplant specialists
- Public awareness campaigns & practical workshops
- Enhanced communication with patient/donor associations
- Assessing the ecological footprint of transplantation